阿拉丁小分子抑制剂、激动剂、拮抗剂--自噬信号通路-上海阿拉丁生化科技股份有限公司

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阿拉丁小分子抑制剂、激动剂、拮抗剂--自噬信号通路

2020-06-23

自噬

自噬是一个吞噬自身细胞质蛋白或细胞器并使其包被进入囊泡，并与溶酶体融合形成自噬溶酶体，降解其所包裹的内容物的过程。在哺乳动物细胞中，自噬主要有三种类型：微自噬、巨自噬和分子伴侣介导的自噬(CMA)。微自噬通过溶酶体的膜直接包裹待降解物质等，并在溶酶体内降解。巨自噬则由双层膜囊泡包裹待降解物质然后运送到溶酶体中降解。而在分子伴侣介导的自噬(CMA)过程中，分子伴侣识别待降解蛋白，去折叠后并转移目的蛋白至溶酶体内。

自噬通常发生在营养缺乏的情况下，也与发育、分化、神经退行性疾病、应激、感染和癌症等生理和病理过程有关。自噬机制的受损与肿瘤、神经退行性疾病、代谢相关疾病、免疫性疾病等发病过程密切相关。

自噬信号通路转导过程

巨自噬：（1）起始：UKL和Beclin 1蛋白复合物起始自噬泡的形成。（2）延伸：Atg5-Atg12-Atg16L复合物形成并与自噬泡融合；微管相关蛋白轻链3（LC3）由可溶解形式（LC3-I）转变为脂溶形式（LC3-II），与自噬泡结合形成自噬体。（3）融合与降解：自噬体捕获需降解或清除的蛋白质、细胞器等物质；自噬体与溶酶体融合形成自噬溶酶体，释放内容物降解，完成自噬。

线粒体自噬：属于选择性自噬，主要是降解细胞中损伤和不需要的线粒体。线粒体处于健康状态时，PINK 蛋白通过PARL的促进持续降解，而当线粒体功能障碍时， PINK蛋白会处于稳定状态，从细胞质中招募E3泛素连接酶Parkin，来诱导线粒体自噬。Parkin会诱导线粒体膜蛋白的聚泛素化，由此导致通过LC3-作用区域（LIR）与LC3结合的自噬受体蛋白的SQSTM1/p62，NBR1和Ambra1聚集。另外，在特定细胞中，BNIP3 和 BNIP3L/NIX（也存在LIR）可通过非泛素反应机制聚集自噬的相关因子，从而促进自噬体的形成。

自噬信号通路图

产品列表

按靶点分类：

*Autophagy

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50	EC50	Ki	kd	ED50
L124970	LY294002	≥98%	154447-36-6	10mg,25mg,50mg	无细胞	p110α	0.5 μM
						p110δ	0.57 μM
						p110β	0.97 μM
						DNA-PK	1.4 μM
P106869	紫杉醇	99%	33069-62-4	10mg,50mg,250mg,1g,5g	人内皮细胞	Microtubule	0.1 pM
P106868	紫杉醇	分析标准品,≥99%	33069-62-4	10mg	人内皮细胞	Microtubule	0.1 pM
W100984	Wortmannin	98%	19545-26-7	5mg,10mg,25mg	无细胞	PI3K	3 nM
						DNA-PK	16 nM
						ATM	150 nM
						MLCK	170 nM
M129496	3-甲基腺嘌呤	98%	5142-23-4	50mg,250mg,1g,5g,25g	HeLa细胞	Vps34	25 μM
M129496	3-甲基腺嘌呤	98%	5142-23-4	50mg,250mg,1g,5g,25g	HeLa细胞	PI3Kγ	60 μM
N129755	Nocodazole	≥99%	31430-18-9	10mg,50mg		Abl	0.21 μM
						Abl(E255K)	0.53 μM
						Abl(T315I)	0.64 μM
C129284	磷酸氯喹	≥99%	50-63-5	5g,10g,25g,100g,500g		ATM
A134451	Azithromycin	分析标准品	83905-01-5	25mg
P170364	PFK15	98% (HPLC)	4382-63-2	5mg,25mg		PFKFB3	207 nM
S166799	Spautin-1	98% (HPLC)	1262888-28-7	5mg,25mg		USP10	0.5779 μM
S166799	Spautin-1	98% (HPLC)	1262888-28-7	5mg,25mg		USP13	0.6916 μM
S105956	青藤碱盐酸盐	97%	6080-33-7	1g,5g
S101688	青藤碱盐酸盐	分析标准品,≥97%	6080-33-7	20mg
H141480	硫酸羟基氯喹	≥98%	747-36-4	250mg,1g,5g,25g		TLR9
V125336	Vorinostat	≥99.0%	149647-78-9	100mg,500mg,1g,5g
A127419	ABT-737	≥97%	852808-04-9	5mg,25mg,100mg	无细胞	Bcl-xL		78.7 nM
						Bcl-2		30.3 nM
						Bcl-w		197.8 nM
Y129399	Y-27632 dihydrochloride	≥98%	129830-38-2	5mg,10mg,50mg,100mg		ROCK1			140 nM
Y129399	Y-27632 dihydrochloride	≥98%	129830-38-2	5mg,10mg,50mg,100mg		ROCK2			300 nM
S293790	Rapamycin	≥95%(HPLC)	53123-88-9	50mg,250mg,1g	HEK293细胞	mTOR	~0.1 nM
S115842	Rapamycin	≥98%(HPLC)	53123-88-9	10mg,25mg,50mg,250mg,1g	HEK293细胞	mTOR	~0.1 nM
E129310	Erlotinib HCl (OSI-744)	≥99%	183319-69-9	100mg,500mg,1g,5g	无细胞	EGFR	2 nM
O127383	Obatoclax Mesylate	≥97%	803712-79-0	5mg,10mg,50mg,100mg	无细胞	Bcl-2			0.22 μM
P125961	PI-103	≥98%	371935-74-9	10mg,50mg,100mg	无细胞	p110α	2 nM
						p110β	3 nM
						p110δ	3 nM
						p110γ	15 nM
						mTOR/DNA-PK	30 nM
						mTOR/DNA-PK	23 nM
G120180	盐酸吉西他滨	98%	122111-03-9	10mg,50mg,250mg,1g,5g,25g	PANC1细胞	DNA合成	50 nM
					MIAPaCa2细胞		40 nM
					BxPC3细胞		18 nM
					Capan2细胞		12 nM
P129635	PP242	≥98%	1092351-67-1	5mg,10mg,50mg	无细胞	mTOR	8 nM
P129635	PP242	≥98%	1092351-67-1	5mg,10mg,50mg	无细胞	DNA-PK	0.41 μM
T127425	Temozolomide	≥98% (HPLC)	85622-93-1	250mg,500mg,1g,5g25g,100g
M107827	Metformin hydrochloride	97%	1115-70-4	5g,25g,100g,500g
F122336	Fasudil Hydrochloride	98%	105628-07-7	100mg,250mg,500mg,1g,5g		ROCK2			0.33 μM
						PKA			1.6 μM
						PKG			1.6 μM
						PKC			3.3 μM
						MLCK			36 μM
T101373	他莫昔芬柠檬酸盐	99%	54965-24-1	1g,5g,25g		ER
T129642	Torin 1	≥97%	1222998-36-8	10mg,25mg,50mg	无细胞	mTORC1	2 nM
T129642	Torin 1	≥97%	1222998-36-8	10mg,25mg,50mg	无细胞	mTORC2	10 nM
R107315	白藜芦醇	99%	501-36-0	1g,5g,25g,100g		COX	1.1 μM
R107315	白藜芦醇	99%	501-36-0	1g,5g,25g,100g		LOC	2.7 μM
R107314	白藜芦醇	分析标准品	501-36-0	100mg		COX	1.1 μM
R107314	白藜芦醇	分析标准品	501-36-0	100mg		LOC	2.7 μM
D137736	Dexamethasone	98%	50-02-2	1g,5g,25g
G127944	Gemcitabine	≥99%	95058-81-4	50mg,100mg,250mg,1g,5g,25g
B102375	布雷非德菌素 A	≥98% (HPLC)	20350-15-6	5mg,25mg	HCT 116	ATPase	0.2 μM
G102383	格尔德霉素	≥98% (HPLC)	30562-34-6	10mg,50mg,250mg	SKBr3	p185	70 nM
G102383	格尔德霉素	≥98% (HPLC)	30562-34-6	10mg,50mg,250mg	无细胞	HSP90				1.2 μM
P129961	Pifithrin-α (PFTα)	≥97%	63208-82-2	10mg,50mg		p53
N130841	氯硝柳胺	98%	50-65-7	50g,250g	无细胞	STAT3	0.7 μM
N114456	氯硝柳胺	分析标准品	50-65-7	100mg	无细胞	STAT3	0.7 μM
O118724	奥美拉唑	98%	73590-58-6	1g,5g,25g,100g
A129574	Amiodarone hydrochloride	≥98%	19774-82-4	1g,5g,25g,100g
L129465	Loperamide HCl	≥98%	34552-83-5	5g,25g		μ阿片受体			3.3 nM
L129465	Loperamide HCl	≥98%	34552-83-5	5g,25g		δ阿片受体			48 nM
D129705	地塞米松磷酸钠	≥99%	55203-24-2	50mg,250mg
D129539	卡马西平	≥98.0%	298-46-4	5g,25g,100g		钠离子通道	131 μM
C102161	盐酸可乐定	98%	4205-91-8	250mg,1g,5g,100g		α2肾上腺素能受体					0.02±0.01 mg/kg
F129912	Flubendazole	≥98%(HPLC)	31430-15-6	5g,25g,100g
N129506	Nimodipine	≥98%	66085-59-4	250mg,1g,5g
D102176	乙酸地塞米松	98%	1177-87-3	250mg,1g,5g,25g
N123276	尼群地平	≥95.0%	39562-70-4	25mg,100mg,500mg,1g		钙离子通道	95 nM
S114285	磺胺乙酰钠	分析标准品	127-56-0	250mg,25g
I102722	异钩藤碱	分析标准品,≥98%	6859-01-4	10mg,20mg
T137974	他莫西芬	≥99%	10540-29-1	1g,5g,25g
T137975	他莫西芬	分析标准品,≥99.0% (HPLC)	10540-29-1	50mg
V107236	Vincristine sulfate	98%	2068-78-2	25mg,100mg		微管	32 μM
V107235	硫酸长春新碱	分析标准品,>99%	2068-78-2	10mg		微管	32 μM
S161023	2-丙戊酸钠	≥98.0%	1069-66-5	5g,25g,100g,500g		HDAC
S129300	STF-62247	≥98%	315702-99-9	5mg,25mg,100mg
S171217	Sulfacetamide sodium salt monohydrate	-	6209-17-2	100g,500g		DHPS	9.5 μM
M126521	MG-132	≥98%	133407-82-6	5mg,25mg,100mg,1g		蛋白酶体	100 nM
C153919	Carprofen	>98.0%(HPLC)	53716-49-7	1g,5g,25g,100g		COX-2	3.9 μM
						COX-1	22.3 μM
						FAAH	78.6 μM
H123383	肝素钠	≥180 USP units/mg	9041-08-1	100KU,250KU,500KU,1000KU
H104201	肝素钠	185 USP units/mg	9041-08-1	1g,5g,25g
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g		PARP-1	5 nM
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g		PARP-2	1 nM
D107159	盐酸阿霉素	98%	25316-40-9	25mg,100mg,250mg,500mg,1g,5g
T125887	TAK-242	≥98%	243984-11-4	5mg,10mg,50mg,100mg		NO	1.8 nM
						TNF-R	1.9 nM
						IL-6	1.3 nM
A124869	ABT-199 (GDC-0199)	≥99%	1257044-40-8	10mg,50mg		Bcl-2			＜0.01 nM
B101389	巴佛洛霉素A1	≥95.0 %	88899-55-2	1mg,5mg		V-ATPase
H123383	肝素钠	≥180 USP units/mg	9041-08-1	100KU,250KU,500KU,1000KU
H104201	肝素钠	185 USP units/mg	9041-08-1	1g,5g,25g
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g		PARP-1	5 nM
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g		PARP-2	1 nM
D107159	盐酸阿霉素	98%	25316-40-9	25mg,100mg,250mg,500mg,1g,5g
T125887	TAK-242	≥98%	243984-11-4	5mg,10mg,50mg,100mg		NO	1.8 nM
						TNF-R	1.9 nM
						IL-6	1.3 nM
A124869	ABT-199 (GDC-0199)	≥99%	1257044-40-8	10mg,50mg		Bcl-2			＜0.01 nM
B101389	巴佛洛霉素A1	≥95.0 %	88899-55-2	1mg,5mg		V-ATPase
J166817	(+)-JQ1	98% (HPLC)	1268524-70-4	5mg,25mg		BRD41	77 nM
J166817	(+)-JQ1	98% (HPLC)	1268524-70-4	5mg,25mg		BRD42	33 nM
S131899	SB-203580	≥98%(HPLC)	152121-47-6	5mg,25mg,100mg,500mg		SAPK2a/p38	50 nM
S131899	SB-203580	≥98%(HPLC)	152121-47-6	5mg,25mg,100mg,500mg		SAPK2b/p38β2	500 nM
S125267	SP600125	≥98%	129-56-6	25mg,100mg,500mg,1g,5g		JNK1	40 nM
						JNK2	40 nM
						JNK3	90 nM
C129710	CHIR-99021 (CT99021) HCl	≥98%	252917-06-9	5mg,25mg,100mg		GSK-3α	10 nM
C129710	CHIR-99021 (CT99021) HCl	≥98%	252917-06-9	5mg,25mg,100mg		GSK-3β	6.7 nM
C125082	CHIR-99021	≥98%	252917-06-9	5mg,25mg		GSK-3α	10 nM
C125082	CHIR-99021	≥98%	252917-06-9	5mg,25mg		GSK-3β	6.7 nM
E127109	Enzalutamide	≥98%	915087-33-1	25mg,100mg,250mg,1g,5g	LNCaP前列腺细胞	AR	36 nM
S125098	Sorafenib	≥99%	284461-73-0	250mg,1g		Raf-1	6 nM
						B-Raf	20 nM
						VEGFR-3	22 nM
U127670	U0126-EtOH	≥97%	1173097-76-1	25mg,100mg,500mg		MEK1	70 nM
U127670	U0126-EtOH	≥97%	1173097-76-1	25mg,100mg,500mg		MEK2	60 nM
M129684	MK-2206 2HCl	≥98%	1032350-13-2	10mg,50mg,100mg		Akt1	5 nM
						Akt2	12 nM
						Akt3	65 nM
T127461	Trametinib (GSK1120212)	≥98%	871700-17-3	10mg,50mg,100mg,250mg,500mg,1g		MEK1	2 nM
T127461	Trametinib (GSK1120212)	≥98%	871700-17-3	10mg,50mg,100mg,250mg,500mg,1g		MEK2	2 nM
P126620	PD98059	≥98%	167869-21-8	10mg,50mg		MEK1	2-7 μM
P126620	PD98059	≥98%	167869-21-8	10mg,50mg		MEK2	50 μM
F127328	Forskolin	≥98%	66575-29-9	10mg,50mg,100mg,500mg,1g		腺苷酸环化酶	41 nM	0.5 μM
B125789	Bortezomib (PS-341)	≥98%	179324-69-7	5mg,25mg,100mg,1g		20S 蛋白酶体			0.6 nM
O124003	奥沙利铂	99%	61825-94-3	25mg,100mg,500mg	人黑色素瘤细胞系	C32	0.98 μM
O124003	奥沙利铂	99%	61825-94-3	25mg,100mg,500mg	人黑色素瘤细胞系	G361	0.14 μM
B129693	BAY 11-7082	≥98%	19542-67-7	50mg,250mg,1g		USP7	0.19 μM
B129693	BAY 11-7082	≥98%	19542-67-7	50mg,250mg,1g		USP21	0.96 μM
D129758	Dorsomorphin 2HCl	≥98%	1219168-18-9	5mg,10mg,50mg		AMPK			109 nM
N125522	Necrostatin-1	≥99%	4311-88-0	10mg,50mg		RIP1		182 nM
G125799	Gefitinib (ZD1839)	≥99%	184475-35-2	50mg,250mg,1g,5g,25g,100g	NR6wtEGFR 细胞	EGFR	2-37 nM
D139352	Dorsomorphin	≥98%	866405-64-3	5mg,25mg,100mg		AMPK			109 nM
E125341	Everolimus	≥98%	159351-69-6	10mg,25mg,100mg		mTOR	5-6 nM
A129749	Acadesine	≥98%	2627-69-2	50mg,250mg,1g
D125110	Dasatinib	≥99%	302962-49-8	25mg,100mg,500mg,1g,5g		Abl	0.6 nM
						Src	0.8 nM
						c-Kit	79 nM
						c-KitD816V	37 nM
V129759	Verteporfin	≥97%	129497-78-5	10mg,50mg
D125110	Dasatinib	≥99%	302962-49-8	25mg,100mg,500mg,1g,5g		Abl	0.6 nM
						Src	0.8 nM
						c-Kit	79 nM
						c-KitD816V	37 nM
V129759	Verteporfin	≥97%	129497-78-5	10mg,50mg
D126677	DAPT	≥98%	208255-80-5	5mg,10mg,25mg,50mg		Aβ	115 nM
D126677	DAPT	≥98%	208255-80-5	5mg,10mg,25mg,50mg		Aβ42	200 nM
R126338	Ruxolitinib (INCB018424)	≥98%	941678-49-5	5mg,25mg,50mg,100mg		JAK1	3.3 nM
R126338	Ruxolitinib (INCB018424)	≥98%	941678-49-5	5mg,25mg,50mg,100mg		JAK2	2.8 nM
E121713	Etoposide	98%	33419-42-0	100mg,250mg,500mg,1g,5g
A100625	5-氮胞苷	98%	320-67-2	50mg,250mg,1g,5g,25g
V127521	Vemurafenib (PLX4032, RG7204)	≥98%	918504-65-1	10mg,25mg,50mg,100mg,500mg,1g,5g		RAFV600E	31 nM
V127521	Vemurafenib (PLX4032, RG7204)	≥98%	918504-65-1	10mg,25mg,50mg,100mg,500mg,1g,5g		c-RAF-1	48 nM
S134307	SB 202190	99%	152121-30-7	5mg,25mg,100mg		p38α	50 nM
S134307	SB 202190	99%	152121-30-7	5mg,25mg,100mg		p38β2	100 nM
P125167	Panobinostat (LBH589)	≥98%	404950-80-7	10mg,50mg
I193491	6-乙基鹅去氧胆酸	98%	459789-99-2	50mg,250mg,1g		FXR		99 nM
C174237	CB-839	97%	1439399-58-2	100mg	肾脏	GLS1	23 nM
					脑	GLS1	28 nM
					肝	GLS2	>1 μM

*FKBP

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50
S293790	Rapamycin	≥95%(HPLC)	53123-88-9	50mg,250mg,1g	HEK293细胞	mTOR	~0.1 nM
S115842	Rapamycin	≥98%(HPLC)	53123-88-9	10mg,25mg,50mg,250mg,1g	HEK293细胞	mTOR	~0.1 nM
E125341	Everolimus	≥98%	159351-69-6	10mg,25mg,100mg		mTOR	5-6 nM
T101159	他克莫司	分析标准品,≥98%	104987-11-3	10mg	-	-	-
T101160	他克莫司	≥98%(HPLC)	104987-11-3	50mg,1g	-	-	-
F138016	他克莫司一水合物	≥80.0%(HPLC)	109581-93-3	10mg,50mg,250mg,1g	-	-	-
A127632	Ascomycin	≥97.0%	104987-12-4	25mg,100mg,500mg	-	-	-

*LRRK2

项目号	产品名称	规格	CAS	包装	靶点	IC50
L125224	LRRK2-IN-1	≥99%	1234480-84-2	10mg,50mg,100mg	LRRK2 (G2019S)	6 nM
L125224	LRRK2-IN-1	≥99%	1234480-84-2	10mg,50mg,100mg	LRRK2 (WT)	13 nM
G166851	GSK2578215A	98% (HPLC)	1285515-21-0	5mg,10mg,25mg,50mg,100mg	LRRK2 (G2019S)	8.9 nM
I129698	IKK-16 (IKK Inhibitor VII)	≥99%	873225-46-8	10mg,50mg	IKK2	40 nM
					IKK complex	70 nM
					IKK1	200 nM
					LRRK 2	50 nM
L125224	LRRK2-IN-1	≥99%	1234480-84-2	10mg,50mg,100mg	LRRK2 (G2019S)	6 nM
L125224	LRRK2-IN-1	≥99%	1234480-84-2	10mg,50mg,100mg	LRRK2 (WT)	13 nM
G166851	GSK2578215A	98% (HPLC)	1285515-21-0	5mg,10mg,25mg,50mg,100mg	LRRK2	~10 nM
G166851	GSK2578215A	98% (HPLC)	1285515-21-0	5mg,10mg,25mg,50mg,100mg	G2019S	~10 nM

*CXCR

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50
T103998	单宁酸	AR	1401-55-4	10g,25g,100g,250g,500g	-	CXCR4	-
R126706	Reparixin	≥98%	266359-83-5	5mg,25mg,100mg	-	CXCR1	-
						CXCR2	-
						CXCR8	-
P129846	Plerixafor 8HCl (AMD3100 8HCl)	≥99%	155148-31-5	5mg,10mg,50mg	-	CXCR4	44 nM
P129846	Plerixafor 8HCl (AMD3100 8HCl)	≥99%	155148-31-5	5mg,10mg,50mg	-	CXCR12	5.7 nM
P128026	Plerixafor	≥98%	110078-46-1	10mg,50mg,250mg	无细胞	CXCR4	44 nM
P128026	Plerixafor	≥98%	110078-46-1	10mg,50mg,250mg	无细胞	CXCR12	5.7 nM
D178502	danirixin	97%	954126-98-8	100mg	-	CXCL8	12.5 nM

*Mitophagy

项目号	产品名称	规格	CAS	包装	细胞	靶点	IC50
M129496	3-甲基腺嘌呤	98%	5142-23-4	50mg,250mg,1g,5g,25g		PtdIns3Kγ	60 μM
M129496	3-甲基腺嘌呤	98%	5142-23-4	50mg,250mg,1g,5g,25g		Vps34	25 μM
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g		PARP-1	5 nM
O126162	Olaparib (AZD2281, Ku-0059436)	≥98%	763113-22-0	10mg,25mg,100mg,250mg,1g		PARP-2	1 nM
D107159	盐酸阿霉素	98%	25316-40-9	25mg,100mg,250mg,
S131899	SB-203580	≥98%(HPLC)	152121-47-6	5mg,25mg,100mg,500mg		SAPK2a/p38	50 nM
S131899	SB-203580	≥98%(HPLC)	152121-47-6	5mg,25mg,100mg,500mg		SAPK2b/p38β2	500 nM
M107827	Metformin hydrochloride	97%	1115-70-4	5g,25g,100g,500g
U127670	U0126-EtOH	≥97%	1173097-76-1	25mg,100mg,500mg,		MEK1	70 nM
U127670	U0126-EtOH	≥97%	1173097-76-1	25mg,100mg,500mg,		MEK2	60 nM
D137736	Dexamethasone	98%	50-02-2	1g,25g,100g
A129749	Acadesine	≥98%	2627-69-2	50mg,250mg,1g
R126338	Ruxolitinib (INCB018424)	≥98%	941678-49-5	5mg,25mg,50mg,100mg		JAK1	3.3 nM
R126338	Ruxolitinib (INCB018424)	≥98%	941678-49-5	5mg,25mg,50mg,100mg		JAK2	2.8 nM
E121713	Etoposide	98%	33419-42-0	100mg,250mg,500mg,1g,5g
B102375	布雷非德菌素 A	≥98% (HPLC)	20350-15-6	5mg,25mg	HCT 116	ATPase	0.2 μM
V125336	Vorinostat	≥99%	149647-78-9	100mg,500mg,1g,5g
R107315	白藜芦醇	99%	501-36-0	1g,5g,25g,100g		COX	1.1 μM
R107315	白藜芦醇	99%	501-36-0	1g,5g,25g,100g		LOC	2.7 μM
R107314	白藜芦醇	分析标准品	501-36-0	100mg		COX	1.1 μM
R107314	白藜芦醇	分析标准品	501-36-0	100mg		LOC	2.7 μM
A126970	17-AAG	98%	75747-14-7	25mg,100mg		HSP90	5 nM
M118674	褪黑素	98%	73-31-4	250mg,1g,5g,25g,100g

*Mitophagy

项目号	产品名称	规格	CAS	包装	靶点	IC50
M126461	MRT67307	≥98%	1190378-57-4	10mg,50mg	IKKε	160 nM
					TBK-1	19 nM
					ULK1	45 nM
					ULK2	38 nM

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